2018 9th IEEE Control and System Graduate Research Colloquium (ICSGRC)

1 / 2018-04-03 12:00:12

The Impact of Pulse Electric Field Treatment and Selected Bioactive Compound Extract toward Anti-cancer Treatment

electroporation; bioactive compound; cancer treatment; anti-proliferation

Electroporation (EP) is a method of controlling cell function by using pulses of electrical fields to create pores through cell membrane and causes other substance around it to be absorbed into the cell. This method has led to a variety of medical applications, particularly in cell studies. In this study, a high voltage pulse electric field (HVPG) will be applied on MCF-7 cell (Human Breast cancer cell) to investigate the electroporation process (500, 1000, 1500 and 2000 V/cm). In addition, this study focused on the effectiveness of bioactive extract compound, combined with the pulse parameter, to look at anti-proliferation effect on MCF-7 cell when exposed to high voltage. Thus, will lead towards cell cancer treatment factors plus the presence of electric field as the stimulator for an aggressive adsorption of the bioactive compound extract into the cells. The combination of these two techniques will contribute towards understanding the cell cancer treatment factors which may lead towards an incentive method for cell cancer treatment.