The 30th International Conference on Arabidopsis Research (ICAR 2019)

551 / 2019-03-15 14:26:00

A R. solanacearum type-III effector manipulates plant metabolism to suppress resistance against bacterial wilt disease

R. solanacearum,type III effector,metabolism,bacterial wilt

Plenary track > Biotic Stress

Plants in nature are faced with various abiotic and biotic stresses during their lifetime. The bacterial wilt disease, which is caused by the soil-borne pathogen Ralstonia solanacearum, is one of the most destructive plant diseases worldwide. R. solanacearum can deliver type III effectors (T3Es) via the Type III secretion system (T3SS) to manipulate plant cellular functions, such as plant immunity, plant hormone signaling pathways, metabolism, organelle function, and plant development. This contributes to R. solanacearum proliferation, colony establishment, and spread. In this work, we have found a R. solanacearum T3E that interacts with plant enzymes involved in anaerobic metabolism. A detailed genetic and biochemical characterization of this pathway has allowed us to uncover a novel plant function that mediates resistance against bacterial wilt, as well as its targeting by bacterial type-III effectors as part of the infection process.