2019 International Conference of Geospatial Information and Public Health (GIPH 2019)

82 / 2019-09-09 14:02:10

Differences in the transmission of dengue fever by different serotypes of dengue virus

dengue ,transimission

Track B. Public health related topics > Track B - Default subject

Dengue fever is the most common arbovirus in the world, and all four serotypes are infectious and pathogenic, but DENV-1 and DENV-2 are the most prevalent in Guangdong Province. To investigate the causes of differences in serotypes, we evaluated the replication, pathogenicity, and NS1 expression differences of DENV-2 and DENV-3 in cells, and further investigated the effects of NS1 on viral replication and transmission. The results of this study indicated that DENV-2 replicates faster and is more pathogenic than DENV-3. In Vero cells, DENV-2 secretes more NS1 protein than DENV-3, and NS1 protein promotes infection of DENV by Aedes albopictus and Aedes aegypti. The spread of dengue virus and the severity of the disease depend on many factors. Further research on the differences between different serotypes of dengue virus will help us understand the epidemiology of DENV infection. This will provide a scientific basis for the prevention and control of the dengue epidemic.