Tianjin International Conference on Biomaterials，Bio-Design and Manufacturing (BDMC2019)

76 / 2019-08-30 08:42:30

Research of Dissolving Microneedles based on Antibacterial Property and Cytotoxicity

Dissolving microneedles,Antibacterial property,Cytotoxicity

Plenary track > Novel bio-manufacturing systems and technologies

Dissolving microneedles (MNs) can be completely dissolved after penetrating into the skin, and they have attracted increasing attention in the application of drug delivery. However, the security of dissolving MNs has still not been studied fully, thus obstructing their commercialization in clinical medicine. In this paper, we fabricated chitosan (CS), sodium hyaluronate (HA), and gelatin (Gel) MNs and assessed for their antibacterial property and cytotoxicity. Our research demonstrated that CS MNs possess antibacterial property against Escherichia coli and Staphylococcus aureus and that HA and Gel MNs do not possess antibacterial property. Besides, we also proved that CS, HA, and Gel MNs have low cytotoxicity using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays and that HA and Gel MNs can be beneficial for cell proliferation.