24th International Conference on Phosphorus Chemistry (ICPC24)

134 / 2023-10-23 15:57:15

Application of [TBA][PO2Cl2] in Arylphosphines (PIII) Synthesis

Inorganic phosphorous salts,Organophosphorus Compounds

Given the high demand for organophosphorus compounds (OPCs), developments of sustainable routes toward OPCs synthesis attract much attention. Numerous efforts are contributing to P₄ transformations into P₁ chemistry. Nevertheless, the existing methods necessitate energy-immense multistep often utilize corrosive and dangerous reagents originating from P₄/P_red allotropes, harmful intermediates, and chemical waste, impeding further exploration and practical applications. In this study, we synthesized [TBA][PO₂Cl₂] by preactivating phosphate with oxaloyl chloride, followed by reduction using a reducing agent to obtain a low-valence phosphosilicon intermediate [TBA][P(SiCl₃)₂].^[1-3] This intermediate was then used to synthesize a range of trisubstituted organophosphine compounds, including functionalized trithiophosphates and triarylphosphines.^[4] The potential value of these compounds lies in their ability to reduce reliance on the industrial white phosphorus pathway. X-ray diffraction and DFT calculations confirmed the activation of the intermediate [TBA][PO₂Cl₂].