Abstract Details
187 / 2024-06-15 23:55:04
In Vivo Tumor-Catalyzed Photoacoustic Imaging of Cyclic Cascade Reactions Driven by Multi-Enzyme Active Mesoporous Nanozymes
nanoenzymes,oxidative stress,photoacoustic imaging
Draft Pending
Oxidative stress is closely related to the occurrence and development of a variety of diseases, and is an important target for diagnosis and treatment, but there is a lack of accurate in-situ detection tools. Here, we synthesized nano-enzymes (Au@mIrO2) with excellent POD, OXD, and CAT enzymatic activities via a spontaneous galvanic dissolution and template-Induced regrowth, and utilized three-dimensional (3D) multispectral photoacoustic (PA) molecular imaging to monitor the in vivo cascade of catalytic therapeutics based on the multi-enzyme-driven cyclic reaction platform. Au@mIrO2 targeted to the liver induces changes in oxyHb and deoxyHb content, which, in combination with the PA response of the nano-enzymes, allows for the simultaneous mapping of 3D PA signals of dynamic endogenous and exogenous molecules associated with the catalytic process, leading to real-time, non-invasive in situ visual monitoring of oxidative stress in the liver. In addition, due to the LSPR effect of Au NR in the NIR-Ⅱ, the enhanced PA imaging capability and photothermal and ROS generation can be achieved in the realization of PA imaging for navigated tumor therapy.
Important Date
-
Conference Date
Sep 08
2024
toSep 12
2024
-
Sep 15 2024
Draft paper submission deadline
-
Sep 15 2024
Registration deadline
Sponsored By
ShenZhen University
Contact Information
- Organizing Committee
- ic******@163.com
- +86********
Previous Conferences
-
2009-05-11 China 哈尔滨市
The International Conference on Nanophotonics 2009
