The International Conference on Nanophotonics (ICNP 2024)

227 / 2024-07-30 00:44:33

Rational Manipulation of Excited-States Dynamics in Organic Materials for optimized photodynamic therapy

biophotonics，nanophotonics，photodynamic therapy，ultrafast spectrum

The dynamics of excited states in organic photosensitizers fundamentally determine the performance of clinical photodynamic therapy (PDT). Therefore, it is essential to deepen our understanding of the structure-dynamics relationship with aiming to manipulate excited states accordingly. However, the limited knowledge of excited-state dynamics in organic structures poses significant challenges to such rational manipulations. Our research addresses this gap by focusing on the structure-dynamics relationship in organic materials to enhance PDT performance. We utilized femtosecond transient absorption (fs-TA) spectroscopy to gain insights into excited-state dynamics. Our research on excited-state dynamics in organic molecules revealed that geometry-twisting greatly enhances intersystem crossing (ISC), providing a new way to develop organic materials with external stimuli-responsive reversible switching of ISC. This understanding of ISC can lead to the development of advanced photosensitizers for PDT.