229 / 2024-07-30 08:42:37
Metalens for miniatured two-photon microscopy
Metalens, miniatured two-photon microscopy, geometric phase
Draft Pending
Hui Li / Chinese Academy of Sciences;Laboratory of Advanced Theranostic Materials and Technology; Ningbo Institute of Materials Technology and Engineering
Xiaohu Chen / Jiangsu Key Lab of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
Cong Chen / Jiangsu Key Lab of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences
The miniatured two-photon microscope is promising for monitoring brain activities of free-behaving animals or in-situ endoscope diagnosis. Ultrathin and lightweight metalens presents a potential alternative to bulky refractive lenses for a miniaturized optical system. However, designing and fabricating achromatic metalens covering the near-infrared and visible light spectrum range is challenging. We proposes and demonstrates a metalens focusing at one wavelength while capable of multichannel two-photon microscopy due to the nonlinear properties of two-photon excitation. The metalens was designed solely to focus near-infrared excitation laser using geometric phase regardless of the chromatic correction for visible emission light. Our method simplifies the design process, reduces manufacturing costs, and increases the focusing efficiency for the excitation light while maintaining a high transmittance for visible light. Using the metalens, two-photon biological imaging with three different labels was experimentally demonstrated with subcellular resolution.

The miniatured two-photon microscope is promising for monitoring brain activities of free-behaving animals or in-situ endoscope diagnosis. Ultrathin and lightweight metalens presents a potential alternative to bulky refractive lenses for a miniaturized optical system. However, designing and fabricating achromatic metalens covering the near-infrared and visible light spectrum range is challenging. We proposes and demonstrates a metalens focusing at one wavelength while capable of multichannel two-photon microscopy due to the nonlinear properties of two-photon excitation. The metalens was designed solely to focus near-infrared excitation laser using geometric phase regardless of the chromatic correction for visible emission light. Our method simplifies the design process, reduces manufacturing costs, and increases the focusing efficiency for the excitation light while maintaining a high transmittance for visible light. Using the metalens, two-photon biological imaging with three different labels was experimentally demonstrated with subcellular resolution.

 
Important Date
  • Conference Date

    Sep 08

    2024

    to

    Sep 12

    2024

  • Sep 15 2024

    Draft paper submission deadline

  • Sep 15 2024

    Registration deadline

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ShenZhen University
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