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H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1
ID：119 View Protection：ATTENDEE Updated Time：2024-10-28 14:14:58 Hits：1059 Poster Presentation

Start Time：Pending（Asia/Shanghai）

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Abstract
Repetitive DNA sequences in the genome can cause problems for our cells. To protect the genome, cells turn off these repetitive sequences by placing them in inactive heterochromatic areas and adding repressive markers. However, we don’t know exactly how this is achieved during early embryonic development. Here, we found that the repetitive sequences are densely labeled with an active marker H3K14ac. This marker to our surprise attracts a protein called Eggless/SetDB1 to foster a repressive environment, turning off these repetitive sequences in early fruit fly embryos. Experimentally disrupting this process unleashes many repetitive DNA sequences and harms organismal viability. Our finding uncovers a mode to turn off repetitive sequences in the development of early embryos
 
Keywords
SetDB1,Heterochromatin,H3K14ac
Speaker
陈雨薇
博士研究生 中南大学湘雅医院

Submission Author
陈雨薇 中南大学湘雅医院
袁凯 中南大学
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Important Date

  • Conference Date

    Oct 31

    2024

    to

    Nov 03

    2024

  • Nov 03 2024

    Registration deadline

Sponsored By
崖州湾国家实验室
华中农业大学
浙江大学
中国遗传学会
中国遗传学会三维基因组学专委会
Organized By
中国生物信息学基因组信息学专委会
中国遗传学会表观遗传分会
中国细胞生物学学会染色质生物学分会
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