Abstract Details
68 / 2026-04-05 09:52:08
Construction and Application of a Structure Variant Imputation Reference Panel for Sheep
Structural variants (SVs);,Variant Imputation Reference Panel;,Sheep
Abstract Pending
Structural variants(SVs; >50 bp) have greater regulatory potential than SNVs and short indels, yet most studies focus on smaller variants. Here, we constructed an SV database using HiFisequencing data from 304 sheepsrepresenting 53 breeds distributed across Asia, the Middle East, and Africa. A reference panel (52.4M SNPs, 5.4M indels, 177,420 SVs) was constructed from 5056 high-coverage WGS samples(>120 breeds), and enables accurate SV imputation in low-coverage WGS data (r² > 0.9, concordance > 0.95). Applying this panel to 457 sheeps with paired multi tissue transcriptomes(2,134 samples), we identified 182 SVs as putative causal eQTLs (PIP > 0.8). Expression altering SVs exhibitsignificantly larger effectsizesthan SNVs/indels.
As an example, a 58 kb deletion disrupts multiple exons of CHRNA10 and drivesitsstrong downregulation in the pituitary, illustrating the direct regulatory impact of SVs.
Important Date
-
Conference Date
Apr 16
2026
toApr 19
2026
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Apr 06 2026
Draft paper submission deadline
Sponsored By
西北农林科技大学
西安交通大学
浙江大学
华中农业大学
中国遗传学会三维基因组学专委会
西安交通大学
浙江大学
华中农业大学
中国遗传学会三维基因组学专委会
Organized By
西北农林科技大学
Contact Information
- 苏建明
- su******@nwafu.edu.cn
- 180********
Previous Conferences
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2024-11-01 China 三亚市
第十一届国际三维基因组学研讨会 -
2024-10-31 China 三亚市
The 11th International Symposium on 3D Genomics -
2023-07-14 China 杭州市
第十届国际三维基因组学研讨会 -
2019-10-10 China
第六届国际三维基因组学研讨会
